Los Angeles Rams at San Francisco 49ers
Game Date: 9/12/2016
Game Time: 7:00 PM
Picking: Full Game
Spread
Result: Win
NFL Spread Pick
San Francisco 49ers  +2.5
Pick Write-Up
Los Angeles has an emerging superstar in second-year running back Todd Gurley, who introduced himself to the NFL by rushing for at least 125 yards in each of his first four starts. A non-existent passing game allowed defenses to focus on Gurley as his rookie season progressed, leading to coach Jeff Fisher's decision to promote Case Keenum, who won three of his last four starts. There's still a dearth of talent at wide receiver for Los Angeles, which likes to line up former first-round pick Tavon Austin in the backfield with Gurley rather than stretch defenses with the deep ball. Tackle Aaron Donald is an unstoppable force on defense for the Rams, who must replace defensive end Chris Long and linebacker James Laurinaitis.

Blaine Gabbert started to resurrect his career after he was elevated to starter midway through last season and won the quarterback job in the preseason while Kaepernick was slow to recover from multiple surgeries. Gabbert, who threw for 354 yards in a 19-16 win over the Rams to finish 3-5 last season. Like the Rams, San Francisco will have to cobble together a group of wide receivers, with Torrey Smith the de facto No. 1 after grabbing only 33 receptions in his first season with the 49ers. San Francisco held opponents to 20 points or fewer in seven of eight home games. NINERS DEFENSE WILL BE THE KEY!! TAKE THE 49ERS +2.5, NFL LOCK OF THE NIGHT!!"